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Sonidegib metabolite M48 (2-methyl-3-[4-(trifluoromethoxy)phenyl]benzoic acid) is the primary circulating metabolite of sonidegib, supplied as a research-grade reference standard for pharmacokinetic, metabolic, and analytical studies.
For research use only; not for human or clinical use.
High purity: 98.0%.
White to off-white solid, stable under recommended storage.
Comprehensive analytical data available (COA, HNMR, LC-MS).
Recommended storage: room temperature (solid) for up to 3 years; in solvent: -80°C for 2 years, -20°C for 1 year.
Suitable as a reference standard for PK and metabolism studies.
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An organic polysulfide compound found in garlic that acts as an H2S donor; reduces the survival of prostate cancer PC-3 cells (IC50 = 22 μM) and inhibits the growth of human colon adenocarcinoma HCT15 cells (IC50 = 11.5 μM); suppresses the growth of PC-3 xenografts in vivo in mice and induces vascular smooth muscle relaxation.
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Tempo (CAS 2564-83-2) is a stable nitroxide radical widely employed in biomedical research for its redox-active properties It facilitates the dismutation of superoxide radicals thereby modulating mitochondrial reactive oxygen species (ROS) levels and influencing cellular oxidative stress responses Tempo also serves as an oxidation catalyst particularly in the transformation of primary alcohols to aldehydes Studies indicate that Tempo exerts both antioxidant and mutagenic effects inducing DNA strand breaks and displaying cytotoxic and mutagenic activities in in vitro models such as murine lymphoma cells It is utilized for investigating oxidative stress redox regulation and chemical mutagenesis
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Tetrahydrothiophen-3-one is an endogenous metabolite and a pharmaceutical intermediate used to synthesize thiazole compounds. It is found in natural food and has good safety.
Endogenous metabolite
Pharmaceutical intermediate for synthesizing thiazole compounds
Exists in natural food with good safety
Appearance: Liquid
Color: Colorless to light yellow
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2,6-Dichlorodiphenylamine is an analogue of Diclofenac Sodium and exhibits anti-Candida albicans activity. Diclofenac Sodium is described as a potent and nonselective anti-inflammatory agent that acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells.
Analogue of Diclofenac Sodium.
Exhibits anti-Candida albicans activity.
Potent and nonselective anti-inflammatory agent.
Acts as a COX inhibitor.
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Diallyl disulfide is an organosulfur compound derived from garlic oil. It is reported as an orally active human squalene monooxygenase inhibitor (IC50 ≈400 μM) and has been investigated for anti-inflammatory, antioxidant, antidepressant, and antitumor activities.
Organosulfur compound with molecular formula C6H10S2 and molecular weight 146.27 g/mol.
Orally active squalene monooxygenase inhibitor (IC50 ≈400 μM).
Reported biological activities include anti-inflammatory, antioxidant, antidepressant, and antitumor effects.
High purity analytical grade available (≈98.4% per data sheet).
Storage: store at 4°C under nitrogen; in solution store at -80°C (up to 6 months) or -20°C (up to 1 month).
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